Current Issue : April-June Volume : 2025 Issue Number : 2 Articles : 1 Articles
Hedyotis diffusa Willd. has been known for its potent antibacterial and antifungal activities. The present study investigated the acute toxicity properties, hemodynamic parameters, myeloperoxidase activity and serum procalcitonin levels of H. diffusa on cecal ligation and puncture (CLP)-induced sepsis in Wistar rats. The acute toxicity studies on rats revealed that H. diffusa was non-toxic up to 2000 mg/kg body weight (b.w). H. diffusa-treated septic rats showed to be improved in multiple hemodynamic parameters, including mean arterial pressure, the optical density of blood, myeloperoxidase activity and serum procalcitonin levels. Additionally, H. diffusa helped to improve the survival rate of septic rats (83.34% at 200 mg/kg b.w and 66.67% at 100 mg/kg b.w) as compared to the untreated ones (0%), possibly due to its anti-inflammatory and bacteremia effects. The results indicated that H. diffusa could be used as a potential therapeutic agent for the treatment of sepsis....
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